Study of leptonic CP violation

The "complementary" Ansatz, Tr$(M_\nu)=0$, where $M_\nu$ is the prediagonal neutrino mass matrix, seems a plausible approximation for capturing in a self-contained way some of the content of Grand Unification. We study its consequences in the form of relations between the neutrino masses and CP violation phases.Comment: 8 pages, 1 figure, talk at MRST200

The Relationship between Parkin and Protein Aggregation in Neurodegenerative Diseases

The most prominent changes in neurodegenerative diseases are protein accumulation and inclusion formation. Several neurodegenerative diseases, including Alzheimer's, the Synucleinopathies and Tauopathies share several overlapping clinical symptoms manifest in Parkinsonism, cognitive decline and dementia. As degeneration progresses in the disease process, clinical symptoms suggest convergent pathological pathways. Biochemically, protein cleavage, ubiquitination and phosphorylation seem to play fundamental roles in protein aggregation, inclusion formation and inflammatory responses. In the following we provide a synopsis of the current knowledge about protein accumulation and astrogliosis as a common denominator in neurodegenerative diseases, and we propose insights into protein degradation and anti-inflammation. We review the E3-ubiquitin ligase and other possible functions of parkin as a suppressant of inflammatory signs and a strategy to clear amyloid proteins in neurodegenerative diseases

Investigating the Light Scalar Mesons

We first briefly review a treatment of the scalars in meson meson scattering based on a non-linear chiral Lagrangian, with unitarity implemented by a "local" modification of the scalar propagators. It is shown that the main results are confirmed by a treatment in the SU(3) linear sigma model in which unitarity is implemented "globally". Some remarks are made on the speculative subject of the scalars' quark structure.Comment: 9 pages,3 figures,talk at hadron2001, Protvin

Proof of the cases p≤7p \leq 7 of the Lieb-Seiringer formulation of the Bessis-Moussa-Villani conjecture

It is shown that the polynomial $\lambda(t) = {\rm Tr}[(A + tB)^p]$ has nonnegative coefficients when $p \leq 7$ and A and B are any two complex positive semidefinite $n \times n$ matrices with arbitrary $n$. This proofs a general nontrivial case of the Lieb-Seiringer formulation of the Bessis-Moussa-Villani conjecture which is a long standing problem in theoretical physics.Comment: 5 pages; typos corrected; accepted for publication in Journal of Statistical Physic

Dynamic response studies on aggregation and breakage dynamics of colloidal dispersions in stirred tanks

Aggregation and breakage of aggregates of fully destabilized polystyrene latex particles in turbulent flow was studied experimentally in both batch and continuous stirred tanks using small-angle static light scattering. It was found that the steady-state values of the root-mean-square radius of gyration are fully reversible upon changes of stirring speed as well as solid volume fraction. Steady-state values of the root-mean-square radius of gyration were decreasing with decreasing solid volume fraction as well as with increasing stirring speed. Moreover, it was found that the steady-state structure and shape of the aggregates is not influenced by the applied stirring speed

Thirty Femtograms Detection of Iron in Mammalian Cells

Inorganic nanomaterials and particles with enhanced optical, mechanical or magnetic attributes are currently being developed for a wide range of applications. Safety issues have been formulated however concerning their potential cyto- and genotoxicity. For in vivo and in vitro experimentations, recent developments have heightened the need of simple and facile methods to measure the amount of nanoparticles taken up by cells or tissues. In this work, we present a rapid and highly sensitive method for quantifying the uptake of iron oxide nanoparticles in mammalian cells. Our approach exploits the digestion of incubated cells with concentrated hydrochloric acid reactant and a colorimetric based UV-Visible absorption technique. The technique allows the detection of iron in cells over 4 decades in masses, from 0.03 to 300 picograms per cell. Applied on particles of different surface chemistry and sizes, the protocol demonstrates that the coating is the key parameter in the nanoparticle/cell interactions. The data are corroborated by scanning and transmission electron microscopy and stress the importance of resiliently adsorbed nanoparticles at the plasma membrane.Comment: 18 pages, 6 figure